In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques
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چکیده
منابع مشابه
In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques
A major neuropathological hallmark of Alzheimer's disease is the deposition of amyloid plaques in the brains of affected individuals. Amyloid plaques mainly consist of fibrillar β-amyloid, which is a cleavage product of the amyloid precursor protein. The amyloid-cascade-hypothesis postulates Aβ accumulation as the central event in initiating a toxic cascade leading to Alzheimer's disease pathol...
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Extracellular deposition of the amyloid-β peptide (Aβ) in the brain parenchyma is a hallmark lesion of Alzheimer's disease (AD) and a predictive marker for the progression of preclinical to symptomatic AD. Here, we used multiphoton in vivo imaging to study Aβ plaque formation in the brains of 3- to 4-month-old APPPS1 transgenic mice over a period of 6 months. A novel head fixation system provid...
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ژورنال
عنوان ژورنال: Acta Neuropathologica Communications
سال: 2014
ISSN: 2051-5960
DOI: 10.1186/2051-5960-2-30